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. 2009 Feb 17:500–518. doi: 10.1016/B978-012373944-5.00314-X

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Copyright © 2009 Elsevier Inc. All rights reserved.

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Schematic representation of a paramyxovirus replication cycle. (a) The G/HN protein binds to cell receptors and (b) promotes viral adsorption that results in the fusion of viral envelope with cell membrane mediated by F protein. Then genome is released into the cytoplasm. (c) A set of mRNAs is transcribed using the genome as template. (d) These mRNAs are then translated in specific proteins, some of which are glycosylated in association with the endoplasmic reticulum and the Golgi apparatus. (e) Envelope glycoproteins direct the points where new virions are formed. (f) New genomes produced by RNA replication are incorporated in newly formed virus particles. (g) The mature virus particles are released by budding from the plasma membrane.