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. 2009 Feb 17:500–518. doi: 10.1016/B978-012373944-5.00314-X

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Copyright © 2009 Elsevier Inc. All rights reserved.

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Schematic overview of HRV replication cycle. (a) Virus binds to cell receptor, (b) triggering endocytosis, and (c) genome uncoating. (d) The released positive-strand genome directs the immediate translation (e) of the polyprotein. (f) The nascent polyprotein is cleaved cotranslationally to produce the virus proteins. The RNA synthesis occurs anchored on vesicle membranes. (g) The positive genome is copied by the viral RNA polymerase to form the full-length negative RNA replicative intermediate, which then (h) serves as a template to produce additional positive RNA genomes. (i) The capsid proteins and the newly synthesized RNA genomes are assembled into virions, (j) which are released by cell lysis.