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. 2009 Feb 17:500–518. doi: 10.1016/B978-012373944-5.00314-X

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Copyright © 2009 Elsevier Inc. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Adenovirus replication cycle. The virus binds to the receptor CAR (Coxsackie B and adenovirus receptor) and integrins. After adsorption, virus is internalized by receptor-mediated endocytosis and directed to the nuclear pore where final disassembly occurs. The viral DNA genome is released into the nucleus and the early set of genes are expressed. Early viral gene products mediate further viral gene expression and DNA replication. Then the late viral genes are expressed, generating structural proteins, and assembly of progeny virions occurs. New viruses are released by cell lysis.