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. 2018 Mar 13:365–374.e1. doi: 10.1016/B978-0-7020-6896-6.00025-9

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FIG 25.3 — Unique Subsets of Memory CD8⁺ and CD4⁺ T Cells Reside Within Peripheral Tissues, at Sites of Previous Viral Infection, and Provide Rapid Protection Against Reinfection.

Resident memory CD8⁺ T cells (T_RM) remain localized in the epidermis in skin after herpes simplex virus (HSV) infection. Resident memory CD4⁺ T (T_EM) cells continue to migrate through the dermal layers of skin, with access to blood and lymphoid tissues.