Table 47.1.
‘Type 1’ to ‘Type 2’ shift in pregnancy
| Cell type | Manifestations | Effect |
|---|---|---|
| T cells | ↓ Th1 (IFN-γ-producing) | Suppression |
| ↑ Th2 (IL-4-producing) | ||
| ↑ Treg | ||
| NK cells | Peripheral blood | Suppression |
| ↓ IFN-γ, cytotoxic activity | ||
| ↓ ‘type 1’(decreased IL-18R + NK cells) | ||
| ↑ ‘type 2’(increased ST2L + NK cells) | ||
| Uterus | ||
| ↑ NK3 cells (TGFβ-producing) | ||
| Monocytes | ↑ Numbers, phagocytosis, respiratory burst | ‘Alternative’ activation |
| ↑ CD14 endotoxin receptor expression | ||
| ↑ IL-12 secretion | ||
| Granulocytes | ↑ Numbers, phagocytosis, respiratory burst | Activation |
| Dendritic cells | ↓ CD86, HLA-DR expression | Suppression |
| ↓ IL-12 production | ||
| ↑ IL-10 production |