Skip to main content
. 2010 Mar 17:531–562. doi: 10.1016/B978-0-12-374271-1.00047-2

Table 47.8.

Intrapartum and postpartum dosing of zidovudine

Maternal/intrapartum
  • All HIV-positive mothers:
    • •
      2 mg/kg body weight intravenously over 1 hour, followed by continuous infusion of 1 mg/kg body weight per hour
    • •
      Begin with labor onset, treat until delivery
Neonatal/postpartum
  • Term infants (≥35 weeks):
    • •
      2 mg/kg body weight per dose given orally, OR
    • •
      1.5 mg/kg body weight per dose given intravenously, begun within 6–12 hours or sooner after birth, then given every 6 hours
    • •
      Begin at birth, treat through age 6 weeks
  • 30 weeks up to 35 weeks:
    • •
      2 mg/kg body weight per dose given orally, OR
    • •
      1.5 mg/kg body weight per dose given intravenously, begun within 6–12 hours or sooner after birth, then given every 12 hours; increased to every 8 hours at age 2 weeks
    • •
      Begin at birth, treat through age 6 weeks
  • < 30 weeks:
    • •
      2 mg per kg body weight per dose given orally, OR
    • •
      1.5 mg per kg body weight per dose given intravenously, begun within 6–12 hours or sooner after birth, then given every 12 hours; increased to every 8 hours at age 4 weeks
    • •
      Begin at birth, treat through age 6 weeks