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. 2020 Feb 14;36:100953. doi: 10.1016/j.molmet.2020.01.017

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Intratumoral heterogeneity of spatially correlating metabolites in three human gastric cancer tissue sections, visualized via spatial correlation networks (A–C). Left: Close-up of the HER2/neu positive (red) and negative (yellow) tumor regions. Middle: Spatial correlation networks for metabolites. Edges represent positive (blue) and negative (red) spatial correlations between metabolites. Line thickness and transparency correspond to the correlation coefficient. Right: Zoom-in to glucose 6-phosphate. Abbreviations: glucose 6-phosphate (G6P), glycerol 3-phosphate (Gly3P), ribose 5-phosphate (R5P), S-adenosylhomocysteine (SAH), glycerophosphoinositol (GroPIns), adenosine diphosphate (ADP), guanosine monophosphate (GMP), adenine (Ade), 5-phosphoribosylamine (PRA), reduce flavin adenine dinucleotide (FADH), d-glutamine (DGN), cysteinyl-methionine (C–M), homocysteine (Hcy), phosphatidic acid (PA), phosphatidylglycerol (PG), cyclic phosphatidic acid (CPA), lysophosphatidic acid (LPA), lysophospholipid (LPC), lysophosphatidylinositol (LPI), phosphodimethylethanolamine (P-DME), phosphopantothenate (PPA), dimethyl-2-oxoglutarate (MOG), tetrahydrobiopterin (BH4), O-phosphoethanolamine (PEA), stearic acid (SA). Scale bar, 600 μm.