Table 2.
Diagnostic accuracy of plasma miR-21 and miR-92a to predict clinical colorectal disease with the best predictive cutoffs
| AUC (95%CI) | SE | SP | PPV | NPV | +LR | -LR | |
|---|---|---|---|---|---|---|---|
| For plasma miR-21 | |||||||
| UC vs. non-UC* (> 1.52 fold changes) | 0.844 (0.613 - 0.963) | 87.5 | 91.7 | 92.9 | 85.6 | 10.5 | 0.1 |
| CRC vs. UC (> 5.1 fold changes) | 0.968 (0.854 - 0.996) | 93.5 | 100 | 100 | 94.5 | - | 0.1 |
| For plasma miR-92a | |||||||
| UC vs. non-UC* (> 1.66 fold changes) | 0.979 (0.795 - 0.980) | 87.5 | 100 | 100 | 86.7 | - | 0.1 |
| CRC vs. UC (> 12.91 fold changes) | 0.887 (0.745 - 0.965) | 83.9 | 100 | 100 | 83.9 | - | 0.2 |
* non-UC = irritable bowel syndrome and healthy subjects; AUC: area under the curve; CI: confidence interval; CRC: colorectal cancer; LR: likelihood ratio; NPV: negative predictive value; PPV: positive predictive value, SE: sensitivity; SP: specificity; UC: ulcerative colitis