Table 4.

Neurological signs suggestive of Kennedy’s disease

Site of involvement	Neurological signs
Peripheral motor neuron involvement limited or diffused to the four limbs	- Fasciculations - Cramps - Amyotrophy - Predominant motor deficit in the lower and proximal limbs, - Decrease or abolition of osteo-tendinous reflexes
Progressive peripheral bulbar involvement	- Atrophy of the tongue and fasciculations that may extend to the lips, chin, or perioral area (often with a myokymic appearance). - Dysarthria, with potentially a discreet nasal voice - Dysphagia
Sensory involvement	- Most often subclinical and distal
Absence of evidence of central motor neuron involvement	- Absence of spasticity, clonus, exaggeration and / or diffusion of reflexes, or Babinski’s sign
Postural tremor of the upper limbs