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. 2020 Apr 10;18:163. doi: 10.1186/s12967-020-02331-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — In vitro drug sensitivity test using low attached 3D cell culture system. a MSE samples were treated with carboplatin (50 µM), pemetrexed (5 µM) and pembrolizumab (2.5 nM) in a single or combinatorial manner, N = 4. Cell proliferation readout of each group was shown as value ± SD compared with the corresponding vehicle group (control group). *p-value < 0.05 other groups compared with the control group; ^#p-value < 0.05 combinatorial test groups compared with Carbo and Peme test groups; ^∆p-value < 0.05 C + P + Pembro triple test group compared with C + P combinatorial test group. b PD-L1, CD3 and diagnostic (Dx) marker staining of original cell blocks, scale bar = 100 µm. Arrow: tumour cell. Abbreviations: carboplatin (carbo, C), pemetrexed (peme, P), pembrolizumab (pembro)