Table 2.
Post-transplant outcome relative to nutritional support
| EN group (n = 14) | PN group (n = 28) | p | |
|---|---|---|---|
| Engrafment: | |||
| Neutrophil, days, mean | 17.31 | 16.86 | 0.78 |
| PLT > 20*109, days, mean | 35.67 | 23.14 | 0.04 |
| PLT > 50*109, days, mean | 36.40 | 30,89 | 0.45 |
| Duration of G-CSF, days, mean | 11.62 | 10.46 | 0.51 |
| Oral mucositis: | |||
| Grade 3–4, n, (%) | 5 (35.7) | 3 (10.7) | 0.10 |
| Duration, days, mean | 13.46 | 13.54 | 0.98 |
| aGvHD: | |||
| Grade I-IV, n, (%) | 6 (42.9) | 13 (46.4) | 1.00 |
| Grade III-IV, n, (%) | 1 (16.7) | 5 (38.46) | 0.52 |
| Gut aGvHD, n, (%) | 4 (28.6) | 8 (28.6) | 1.00 |
| Gut aGvHD +++/++++, n, (%) | 0 (0) | 5 (17.9) | 0.08 |
| Steroid Resistant Gut aGvHD, n, (%) | 0 (0) | 6 (21.4) | 0.06 |
| Infections: | |||
| BSI, n, (%) | 2 (14.3) | 15 (53.6) | 0.02 |
| Duration of fever in the first 30 days post HSCT, days, mean | 8.00 | 11.21 | 0.07 |
| Length of Antibiotic therapy in the first 30 days post HSCT, days, mean | 18.54 | 19.38 | 0.65 |
| VOD, n, (%) | 2 (14.3) | 5 (17.9) | 1.00 |
| Length of hospital stay, days, mean | 71.8 | 60.1 | 0.28 |
| Transfer to ICU, n, (%) | 2 (14.3) | 3 (10.7) | 1.00 |
| Nutritional Support: | |||
| Length of nutritional support, days, mean | 20.71 | 30.71 | 0.09 |
| Start of oral realimentation, days, mean | 20.85 | 26.96 | 0.08 |
| Nutritional Parameters | |||
| Lowest weight, Kg, mean | 29.78 | 36.63 | 0.31 |
| Maximum weight loss %, mean | 11.5 | 9.9 | 0.44 |
| Weight loss > 10%, n, (%) | 7 (50) | 9 (32.2) | 0.30 |
| Metabolic Parameters: | |||
| Albumin transfusions, U, mean | 6,31 | 13.79 | 0.14 |
| Hypophosphatemia, n, (%) | 8 (57,1) | 21 (75) | 0.10 |
| γGT and/or direct bilirubin elevation, n, (%) | 11 (78,6) | 24 (85.7) | 0.26 |
Abbreviations: EN= Enteral Nutrition, PN= Parenteral Nutrition, PLT= Platelets, G-CSF= Granulocyte-Colony Stimulating Factor, aGvHD= Acute Graft versus Host Disease, BSI= Blood Stream Infections, HSCT= Hematopoietic Stem Cell Transplantation, VOD= Veno Occlusive Disease, ICU= Intensive Care Unit, γGT= Gamma.glutamyltransferase
Statistical analysis used to calculate the P value: qualitative variables were compared using Fisher’s exact test, while means were compared with t-test corrected in case of unequal variances. p < 0.05 were considered statistically significant and underlined in the table