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. 2020 Apr 11;17:111. doi: 10.1186/s12974-020-01792-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Pro- and anti-inflammatory gene expression at P13 following HI insult at P10. Relative expression of pro-inflammatory (IL-1β, TNF-α, and iNOS) and anti-inflammatory genes (IL-4, IL-10, and TGF-β) was measured by quantitative PCR at P13 in males (a) (DTA⁻ sham, n = 3; DTA⁺ sham, n = 4; DTA⁻ HI, n = 6; DTA⁺ HI, n = 9) and females (b) (DTA⁻ sham, n = 3; DTA⁺ sham, n = 3; DTA⁻ HI, n = 6; DTA⁺ HI, n = 6). All values were normalized to β-actin. The expression levels of the target mRNAs were calculated and compared with the DTA⁻ and sham groups. Values are presented as mean ± SD. *P < 0.05, **P < 0.01. Regarding TNF-α, iNOS, IL-4, and TGF-β expression in males and IL-1β, iNOS, IL-4, and TGF-β expression in females; one-way ANOVA followed by the Sidak multiple comparison test. Regarding IL-β and IL-10 in males and TNF-α and IL-10 in females; Dunn’s multiple comparison test