Table 2.

Effect of drugs or drug combinations on survival of stationary phase B. henselae^a

Drugs (5 μg/ml)	CFU per mL after drug exposure
Drug free control	2.8 ± 0.4 × 1010
Amikacin	8.0 ± 0.2 × 104
Azithromycin	6.5 ± 0.4 × 105
Cefuroxime	2.2 ± 0.2 × 105
Ciprofloxacin	6.0 ± 0.1 × 102
Clofazimine	1.6 ± 0.2 × 1010
Daptomycin	5.0 ± 0.2 × 107
Disulfiram	1.0 ± 0.2 × 107
Doxycycline	8.0 ± 0.3 × 106
Gentamicin	5.0 ± 0.2 × 102
Methylene blue	3.2 ± 0.4 × 104
Miconazole	1.5 ± 0.1 × 1010
Nitrofurantoin	2.8 ± 0.1 × 102
Rifampin	6.0 ± 0.3 × 105
SXT	3.5 ± 0.2 × 106
Azithromycin+Amikacin	4.3 ± 0.3 × 105
Azithromycin+Rifampin	2.0 ± 0.2 × 105
Azithromycin+Cefuroxime	5.2 ± 0.2 × 105
Azithromycin+Ciprofloxacin	0
Azithromycin+Clofazimine	2.2 ± 0.3 × 106
Azithromycin+Daptomycin	1.8 ± 0.1 × 105
Azithromycin+Disulfiram	1.4 ± 0.2 × 105
Azithromycin+Doxycycline	1.2 ± 0.3 × 106
Azithromycin+Gentamicin	5.1 ± 0.3 × 104
Azithromycin+Methylene blue	0
Azithromycin+Miconazole	1.3 ± 0.2 × 105
Azithromycin+Nitrofurantoin	4.0 ± 0.3 × 105
Azithromycin+SXT	8.5 ± 0.1 × 106
Rifampin+ Amikacin	1.6 ± 0.1 × 105
Rifampin+Cefuroxime	2.2 ± 0.1 × 104
Rifampin+Ciprofloxacin	0
Rifampin+Clofazimine	2.8 ± 0.1 × 105
Rifampin+Daptomycin	1.2 ± 0.1 × 106
Rifampin+Disulfiram	8.5 ± 0.2 × 105
Rifampin+Doxycycline	1.2 ± 0.1 × 106
Rifampin+Gentamicin	1.6 ± 0.1 × 104
Rifampin+Methylene blue	0
Rifampin+ Miconazole	8.0 ± 0.3 × 105
Rifampin+Nitrofurantoin	1.2 ± 0.1 × 105
Rifampin+SXT	1.6 ± 0.1 × 105

^aStationary phase B. henselae (6-day old) cells were treated with 5 μg/ml drugs alone or drug combinations for 24 h when the survival of the bacteria was determined by CFU count after wash (see Methods for more details)