Fig. 12.

Muscles from the moderate FHSD-like model mice undergo apoptosis in response to induced DUX4-fl expression. TA muscles from female moderate model mice that had undergone treadmill exhaustion analysis 2× per week (see Fig. 8) were assayed at MD6 (a, e), MD14 (b, f), and MD28 (c, g) or at MD28 for matched mild model mice (d, h). Green signal in the TUNEL assay (a–d) indicates nuclei undergoing apoptosis, compared with DAPI staining (e–h) showing all nuclei in the same histological sections. Scale bar = 200 μm. Quantitative analysis of data is shown in Figure S14