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. 2017 Oct 4;145:263–283. doi: 10.1016/B978-0-12-802395-2.00019-5

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Fig. 19.9 — Active stage of neuromyelitis optica (NMO) lesion. An active NMO lesion shows inflammatory infiltrates with eosinophils (A, hematoxylin and eosin) next to macrophages and lymphocytes, deposition of immunoglobulin G (B, IgG), and C9 neoantigen (C, arrows). Some lesions show selective loss of aquaporin-4 (D, asterisk marks lesion) while aquaporin-1 is well preserved (E) and there is accumulation of bizarre astrocytes with beading and clumping of cell processes (clasmatodendrosis) (F, glial fibrillary acidic protein). A, B, F, × 600; C, × 200; D, E, × 100.