Table III.
Examples of Mouse Strain Nomenclature
| Strain name | Definition |
|---|---|
| DBA/2J | Inbred strain named for its characteristic coat color genes (using their original gene symbols), dilute (d), brown (b), and nonagouti (a); it is the second of two sublines separated before 20 generations of brother × sister breeding and is the subline maintained at the Jackson Laboratory (J) |
| C3H/HeSn-ash/+ | Coisogenic segregating inbred mutant strain carrying the ashen (ash) mutation, which arose on C3H/HeSn |
| C57BL/6J-TyrC-2J/+ | Coisogenic segregating inbred mutant strain carrying the albino 2J mutant allele of the cloned tyrosinase gene (tyr) |
| AEJ/GnJ-ae/A w-J | Inbred strain segregating for two alleles at the agouti gene |
| AKR.B6-H2b | Congenic inbred strain in which the b haplotype at the H2 complex was transferred from C57BL/6J (B6) to the AKR background |
| B6.CBA-D4Mit25-D4Mit80 | Congenic strain in which the chromosomal segment between D4Mit25 and D4Mit80 was transferred from CBA to B6 |
| B6.Cg m Leprdb/+ + | Congenic inbred strain in which the linked mutant genes misty (m) and diabetes (Lepr db) were transferred from multiple, mixed, or unknown genetic backgrounds to B6 and are carried in coupling, i.e., on the same chromosome |
| B6.Cg-m +/+ Lepr db | Congenic inbred strain in which the m and Lepr db mutations are carried in repulsion |
| BXD-1/Ty | Recombinant inbred (RI) strain number 1 in a set of RI strains derived from a C57BL/6J (B) female mated to a DBA/2J (D) male and made by Taylor (Ty) |
| CcS1 | Recombinant congenic (RC) strain number 1 in a set made by crossing the BALB/c (C) and STS (S) strains, backcrossing 1 or 2 times to BALB/c and then inbreeding as with RI strains |
| CcSI(N4) | Recombinant congenic (RC) strain number 1 in a set made by crossing the BALB/c (C) and STS (S) strains, backcrossing N4 times to BALB/c and then inbreeding as with RI strains |
| B.A-Chr 1 | Chromosome substitution (CSS) or consomic strain in which Chr 1 from A/J has been transferred to the B6 background |
| C57BL/6J-mt BALB/c | Conplastic strain with the nuclear genome of C57BL/6J, and the cytoplasmic genome of BALB/c, developed by crossing male C57BL/6J mice with BALB/c females, followed by repeated backcrossing of female offspring to male C57BL/6J |
| B6; 129-Cfir tmlnc | First targeted mutation of the cystic fibrosis transmembrane regulator gene created at the University of North Carolina, Unc, and carried on a mixed B6 and 129 background |
| B6.129-Myf5Myod | Congenic strain carrying a replacement or “knockin” in which the Myf5 gene was replaced with the Myod gene in 129 ES cells and backcrossed onto the B6 genetic background |
| FVB/N-TgN(MBP) 1Xxx | Transgene in which the human myelin basic protein (MBP) gene is inserted into the genome of the National Institutes of Health (N) subline of the FVB strain originally maintained at the National Institutes of Health |
| FVB/N-mTg lzzz | Insertional mutation caused by the TglZzz transgene made on the FVB/N genetic background |
| B6C3F1 | F1 hybrid made by crossing a C57BL/6 female to a C3H male |
| B6EiC3-Ts65Dn | Strain maintained by backcrossing mice with the Ts65Dn chromosome aberration to F1 hybrid mice made by crossing females of the Eicher (Ei) subline of C57BL/6 × C3H; note that these mice are not true F1 hybrids, and the F1 designation is omitted |
| Hsd:ICR | ICR outbred stock maintained at Harlan (Hsd) |
| Pri:B6, D2-G# | Advanced intercross line (AIL) created at Princeton (Pri) from the inbred strains C57BL/6 × DBA/2; AlL are made similar to RI strains except mice are intercrossed, avoiding sibling matings, to increase the possibility of tightly linked genes recombining |