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Invasive adenocarcinoma of prostate. (A) H&E of invasive adenocarcinoma of prostate. By H&E alone, the differential diagnosis includes invasive adenocarcinoma and adenosis. (B) High molecular weight cytokeratin immunostain of invasive adenocarcinoma of prostate. Loss of high molecular weight cytokeratin (34βE12) immunoreactivity around the glands of interest supports a diagnosis of invasive adenocarcinoma.
