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Frank Fenner’s classic study of the pathogenesis of ectromelia (mousepox) viral infection. This was the first study ever done using serial (daily) titration of the viral content of organs and tissues, and the model for many studies that have since advanced knowledge of the pathogenesis of systemic viral infections.
[From F. Fenner. Mousepox (infectious ectromelia of mice): a review. J. Immunol.63, 341–373 (1949), with permission.]
