Figure 3.14.

Injection of lymphocytic choriomeningitis virus (LCMV) into a newborn mouse produces a persistent infection with only minor pathological changes (top). Intracerebral injection of a normal adult mouse produces a fulminating disease that quickly kills the animal (middle). However, a T-deficient mouse (e.g. neonatally thymectomized or treated with anti-thymocyte serum) tolerates an intracerebral injection of LCMV (bottom). This carrier state can be broken by an injection of T cells (but not serum) from a mouse acutely ill with LCM.

(Adapted from Introduction to Immunology. J. W. Kimball, p. 462. Copyright 1983 MacMillan Publishing, with permission.)