Table I.
Commonly Used Rat Strains
| Inbred strains | Usefulness as models |
|---|---|
| ACI | Congenital genitourinary anomalies, prostatic adenocarcinomas |
| BB/Wor | Juvenile insulin-dependent diabetes mellitus |
| BN (Brown Norway) | Inducible, transplantable myeloid leukemia, hydronephrosis, bladder carcinoma |
| BUF (Buffalo) | Spontaneous autoimmune thyroiditis, host for transplantable Morris hepatoma |
| COP (Copenhagen) | Prostate adenocarcinoma |
| F-344 (Fischer 344) | Inbred rat model for National Toxicology Program's |
| Carcinogen Bioassay Program and the National | |
| Institute on Aging | |
| LEW (Lewis) | Multiple sclerosis, various experimentally induced autoimmune diseases |
| LOU/C | Myeloma, production of IgG autoantibody |
| SHR (spontaneous hypertensive rat) | Hypertension, cardiovascular research |
| WF (Wistar-Furth) | Mononuclear cell leukemia |
| Zucker | Obesity |
| Mutant strains | Characteristics |
| Brattleboro | Diabetes insipidus (autosomal recessive) |
| Gunn | Jaundice, kernicterus (autosomal recessive) |
| Nude | T cell deficient (autosomal recessive) |
| Obese SHR | Type 4 hyperlipoproteinemia (autosomal recessive) |