Table 22.2.

Neoplasia in Cetaceans Since the Comprehensive Review in 2006^*

Species	Tumor Type	Location
Atlantic spotted dolphin	Astrocytomam	Brain
	Leiomyoman	Uterus
	Pheochromocytomao	Adrenal gland
	Seminoma, sertoli cell tumoro	Testicle
	T-cell lymphomap	Uterus
Beluga whale	Adenocarcinomaa	Stomach
		Intestine
		Uterus
	Adenocarcinoma/lymphagiosarcoma	Adrenal gland
	Carcinoma	Thyroid gland
		Mammary gland
		Lung
	Dysgerminoma	Ovary
	Squamous cell carcinoma	Urethra
		Lung (metastasis)
		Vertebra (met)
Bottlenose dolphin	Immunoblastic lymphomaq	Hepatosplenic
	Leiomyomar	Stomach
	Papillomas	Tongue
		Penis
	Seminomao	Testicles
	Squamous cell carcinomas, t	Oral cavity
Harbor porpoise	Granulosa cell tumorj	Ovary
	Squamous cell carcinomak	Stomach
Long-finned pilot whale	Carcinomag	Lung
Pygmy sperm whale	Leiomyosarcomai	Gastrointestinal tract
Risso’s dolphin	Luteomah	Ovary
Short beaked common dolphin	Hemangiomab	Lung
	Meningiomac, d	Brain
	Sertoli cell tumor, interstital (Leydig) cell tumor, seminomae	Testicles
	T-cell lymphomae	Central nervous system
	Transitional cell carcinomaf	Urinary bladder
Striped dolphin	Primitive neuroectodermal tumorl	Brain

^aLair, S., Martineau, D., Measures, L.N., 2014. Causes of mortality in St. Lawrence Estuary beluga (Delphinapterus leuca), from 1983 to 2012. Ottawa, Canada: Canadian Science Advisory Secretariat.

^bDiaz-Delgado, J., Arbelo, M., Sacchini, S., Quesada-Canales, O., Andrada, M., Rivero, M., Fernandez, A., 2012a. Pulmonary angiomatosis and hemangioma in common dolphins (Delphinus delphis) stranded in Canary Islands. J. Vet. Med. Sci. 74(8), 1063–1066.

^cMiclard, J., Mokhtari, K., Jouvion, G., Wyrzykowski, B., Van Canneyt, O., Wyer, M., Colle, M. A., 2006. Microcystic meningioma in a dolphin (Delphinus delphis): immunohistochemical and ultrastructural study. J. Comp. Pathol. 135, 254–258.

^dDíaz-Delgado, J., de los Monteros, A. E., Fernandez-Maldonado, C., Arbelo, M., Quesada-Canales, O., Andrada, M., Fernandez, A., 2012b. Mixed testicular neoplasia in a short beaked common dolphin Delphinus delphis. Dis. Aquat. Organi. 101, 257–260.

^eArbelo, M., de los Monteros, A.E., Herraez, P., Suarez-Bonnet, A., Andrada, M., Rivero, M., Grau-Bassas, E.R., Fernandez, A., 2014. Primary central nervous system T-cell lymphoma in a common dolphin (Delphinus delphis). J. Comp. Pathol. 150, 336–340.

^fAlonso-Farré, J.M., Gonzalo-Orden, M., Llarena-Reino, M., Monreal-Pawlowsky, T., Degollada, E., 2013. Transitional cell carcinoma in the urinary bladder of a common dolphin (Delphinus delphis) with emphasis on imaging diagnosis. Imaging 6, 1.

^gSuárez-Santana, C. M., Fernández-Maldonado, C., Díaz-Delgado, J., Arbelo, M., Suarez-Bonnet, A., de los Monteros, A. E., Camara, N., Sierra, E., Fernandez, A., 2016. Pulmonary carcinoma with metastasis in a long-finned pilot whale (Globicephala melas). BMC Vet. Res. 12, 229.

^hNishina, H., Izawa, T., Ozaki, M., Kuwamura, M., Yamate, J., 2017. Unilateral luteoma of the ovary in a pregnant Risso’s dolphin (Grampus griseus). J. Vet. Med. Sci. 79(10), 1749–1752.

ⁱLeone, A., Dark, M., Kondo, H., Rotstein, D.S., Kiupel, M., Walsh, M.T., Erlacher-Reid, C., Gordon, N., Conway, J.A., 2013. Gastrointestinal leiomyosarcoma in a pygmy sperm whale (Kogia breviceps). J. Zoo Wildl. Med. 44, 744–748.

^jSeibel, H., Siebert, U., Schöpper, H., Wohlsein, P., 2012. Granulosa cell tumour in a harbour porpoise (Phocoena phocoena) from German waters. Dis. Aquat. Organ. 99, 79–83.

^kSiebert, U., Hasselmeier, I., Wohlsein, P., 2010. Immunohistochemical characterization of a squamous cell carcinoma in a harbour porpoise (Phocoena phocoena) from German waters. J. Comp. Pathol. 143, 179–184.

^lBaily, J., Morrison, L.R., Patterson, I., et al., 2013. Primitive neuroectodermal tumour in a striped dolphin (Stenella coeruleoalba) with features of ependymoma and neural tube differentiation (medulloepithelioma). J. Comp. Pathol. 149, 514–519.

^mDíaz-Delgado, J., Sacchini, S., Suárez-Bonnet, A., et al., 2015a. High-grade astrocytoma (glioblastoma multiforme) in an Atlantic spotted dolphin (Stenella frontalis). J. Comp. Pathol. 152, 278–282.

ⁿDíaz-Delgado, J., Fernández, A., Edwards, J., et al., 2015b. Uterine leiomyoma and prolapse in a live-stranded atlantic spotted dolphin (Stenella frontalis). J. Comp. Pathol. 153, 58–63.

^oEstep, J.S., Baumgartner, R.E., Townsend, F., Pabst, D.A., Mclellan, W.A., Friedlaender, A., Dunn, D.G., Lipscomb, T.P., 2005. Malignant seminoma with metastasis, Sertoli cell tumor, and pheochromocytoma in a spotted dolphin (Stenella frontalis) and malignant seminoma with metastasis in a bottlenose dolphin (Tursiops truncatus). Vet. Pathol. 42(3), 357–359.

^pDíaz-Delgado, J., Sierra, E., Arbelo, M., et al., 2015c. Primary uterine T-cell lymphoma with metastasis in an Atlantic spotted dolphin (Stenella frontalis), Canary islands, Spain. J. Wildl. Dis. 51, 538–541.

^qJaber, J.R., Perez, J., Carballo, M., Arbelo, M., de los Monteros, A.E., Herráez, P., Munoz, J., Andrada, M., Rodriguez, F., Fernández, A., 2005. Hepatosplenic large cell immunoblastic lymphoma in a bottlenose dolphin (Tursiops truncatus) with high levels of polychlorinated biphenyl congeners. J. Comp. Pathol. 132(2), 242–247.

^rRotstein, D., Harms, C., Lovewell, G., et al., 2007. Gastric leiomyoma in a free-living Atlantic bottlenosed dolphin (Tursiops truncatus). Vet. Rec. 160, 130.

^sBossart, G.D., Ghim, S.J., Rehtanz, M., Goldstein, J., 2005. Orogenital neoplasia in Atlantic bottlenose dolphins (Tursiops truncatus). Aquat. Mamm. 31(4), 473.

^tMarch, D.T., Blyde, D.J., Bossart, G.D., Begg, A.P., Taylor, D.P., McClure, V., 2016. Piroxicam and doxycycline treatment for an oral squamous cell carcinoma in an inshore bottlenose dolphin (Tursiops aduncus). Aust. Vet. J. 94(6), 203–207.

^*Source: Newman, S.J., Smith, S.A., 2006. Marine mammal neoplasia: a review. Vet. Pathol. 43(6), 865–880 Available from: http://journals.sagepub.com/doi/abs/10.1354/vp.43-6-865.