Figure 4.
LDL-Receptor Upregulation by Statins on Human Primary NK Cells
(A) Viability of NK cells after 36 h stimulation with different compounds as previous described. Human primary NK cells were co-cultured with compounds for 36 h at a density of 0.1 × 106/mL. NK cells were pre-activated overnight in RPMI-1640 with 1,000 U/mL IL-2. (B) The LDLR expression on primary NK cell was upregulated by rosuvastatin, however, in the non-statin groups no significant difference was found when compared to medium. (C) Overlay histogram of LDLR expression on NK cells stimulated 36 h with different compounds. Data are from n = 6 independent experiments performed at different times. Data analysis was performed by a two-way ANOVA and Bonferroni post-tests in comparison to medium. For cell viability, Mann-Whitney U test was used to compare with medium group.