Figure 5.

Niclosamide inhibits ovarian carcinoma cell growth in vivo. A. Representative images of sacrificed mice from physiological saline and Niclosamide treated groups. B. Representative images of dissected tumors obtained from mice after treatment with physiological saline and Niclosamide. C. Tumor volume in each mouse was monitored every two days. Data are presented as mean ± SE (n = 6). D. Changes in tumor weight in mice treated with saline or Niclosamide. Data are presented as mean ± SE (n = 6). E. Changes in body weight in saline- or Niclosamide-treated mice. Data are presented as mean ± SE (n = 6). F. Western blot analyses of p-MSK1, p-MEK1/2, MEK1/2, p-ERK1/2, and ERK1/2 pathways in tumor tissues derived from saline- or Niclosamide-treated mice. Actin was used as a loading control.