Table 2.
Multivariate analyses of cancer-specific survival in patients with SPT.
|
Characteristic |
All patients | Derivation set | |||||
|---|---|---|---|---|---|---|---|
| No. of patient (n=25983) | HR (95% CI) | P | No. of patient (n=18175) | HR (95% CI) | P | ||
| Age | <0.001 | <0.001 | |||||
| ≤65 | 13740 | 1 | 9545 | 1 | |||
| >65 | 12243 | 1.061 (1.029, 1.093) | 8630 | 1.341 (1.293, 1.389) | |||
| Gender | 0.738 | 0.189 | |||||
| Male | 13155 | 1 | 9177 | 1 | |||
| Female | 12898 | 0.995 (0.967, 1.024) | 8998 | 0.977 (0.944, 1.011) | |||
| Race | 0.083 | <0.001 | |||||
| White | 19868 | 1 | 13948 | 1 | |||
| Black | 3945 | 1.034 (0.993, 1.077) | 2689 | 1.095 (1.043, 1.149) | |||
| Other | 2170 | 0.965 (0.915, 1.018) | 1538 | 0.932 (0.875, 0.993 ) | |||
| Site | 0.004 | <0.001 | |||||
| Left | 9552 | 1 | 6679 | 1 | |||
| Right | 16431 | 1.047 (1.015,1.080) | 11496 | 1.245 (1.199, 1.291) | |||
| Grade | <0.001 | <0.001 | |||||
| Grade I/II | 17146 | 1 | 11945 | 1 | |||
| Grade III/IV | 8837 | 1.070 (1.038, 1.104) | 6230 | 1.378 (1.328, 1.429) | |||
| T stage | 0.001 | <0001 | |||||
| T1/T2 | 896 | 1 | 634 | 1 | |||
| T3/T4 | 25087 | 1.150 (1.055, 1.254) | 17541 | 1.475 (1.332, 1.633) | |||
| N examined | <0.001 | <0.001 | |||||
| 0-6 | 2658 | 1 | 1844 | 1 | |||
| 7-12 | 6015 | 0.927 (0.880, 0.977) | 4192 | 0.848 (0.797, 0.903) | |||
| 13-18 | 8156 | 0.831 (0.790, 0.874) | 5748 | 0.685 (0.645, 0.728) | |||
| 19-24 | 4425 | 0.776 (0.733, 0.821) | 3094 | 0.602(0.563, 0.644) | |||
| >24 | 4729 | 0.747(0.706, 0.790) | 3297 | 0.538 (0.503,0.575) | |||
| N positive | <0.001 | <0.001 | |||||
| 1-3 | 7782 | 1 | 5421 | 1 | |||
| 4-6 | 5264 | 1.083 (1.039, 1.128) | 3734 | 1.205 (1.147, 1.266) | |||
| 7-9 | 3154 | 1.132 (1.078, 1.188) | 2233 | 1.400 (1.321, 1.483) | |||
| 10-12 | 1926 | 1.192 (1.126, 1.263) | 1334 | 1.754 (1.637, 1.879) | |||
| >12 | 3420 | 1.251 (1.192, 1.313) | 2375 | 1.914 (1.806, 2.028) | |||
| 0 | 4437 | 0.871(0.831, 0.913) | 3078 | 0.723 (0.684, 0.765) | |||
| Chemotherapy | <0.001 | ||||||
| Yes | 16294 | 1 | <0.001 | 11394 | 1 | ||
| No/NA | 9689 | 1.116 (1.083, 1.151) | 6781 | 2.140 (2.064, 2.220) | |||
Left: descending colon and sigmoid colon; Right: cecum, ascending colon, hepatic flexure, transverse colon and splenic flexure; N: lymph node; NA: not available.