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The general view of multiple targets or regulated molecules contributing to the bidirectional regulatory effects of miR-186 on cisplatin sensitivity. The final effects of PTEN and APAF1 outweighed PIK3R3 when miR-186 at low concentration so as to increase the cisplatin sensitivity of ovarian cancer cells, while the final effects of PIK3R3 outweighed PTEN and APAF1 when miR-186 at high concentration so as to decrease the cisplatin sensitivity.
