Figure 6.

Per2 regulates proliferation and apoptosis in OSCC cells dependent on autophagy. (A) Western blotting indicated that the LC3B II/I ratio was markedly downregulated and p62 and Beclin1 expression were evidently increased in Per2-OE cells owing to the addition of autophinib. (B) Flow cytometry showed that the proliferation percentage of Per2-OE cells was obviously expanded because of autophinib. (C) Flow cytometry showed that the apoptotic index of Per2-OE cells was significantly decreased because of autophinib. All data represent three independent experiments. Data are presented as the mean ± SD (n ≥ 3). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.