Table 2.

Univariate and multivariate analyses of clinicopathologic parameters associated with recurrence-free survival and overall survival

Variables	Categories	Umivariate analysis				Multivariate analysis
		HR	95%Cl		p value	HR	95%Cl		p vaule
Recurrence-Free Survival
Gender	Male/female	1.061	0.613	1.158	0.923	-	-	-	NA
Age(years)	≥60/<60	0.811	0.687	0.671	0.345	-	-	-	NA
Tumor location	Colon/recsum	1.241	0.905	1.715	0.143	-	-	-	NA
Tumor size(cm)	≥5/<5	1.365	1.271	1.718	0.025	1.179	1.087	1.397	0.048
Differentiation grade	Poor/well+moderate	1.324	1.198	1.593	0.046	-	-	-	NS
Local invasion	pT3-4/pT1-2	1.831	1.522	1.796	0.014	1.471	1.288	1.655	0.038
Lymph node metastasis	N2/N0+N1	1.792	1.502	2.116	0.019	-	-	-	NS
TNM stage	Ⅲ/Ⅰ+Ⅱ	1.927	1.6901	2.414	0.011	1.569	1.245	2.197	0.019
CA19-9 (KU/L)	≥37/<37	1.066	0.676	1.519	0.156	-	-	-	NA
CEA (ng/mL)	≥5/<5	1.196	1.065	1.468	0.042	-	-	-	NS
miR-365a-3p	low/high	1.361	1.148	1.975	0.022	1.187	1.063	1.641	0.045
Overall Survival
Gender	Male/female	1.162	0.751	1.487	0.939	-	-		NA
Age(years)	≥60/<60	1.138	0.634	1.158	0.432	-	-	-	NA
Tumor location	Colon/recsum	1.097	0.948	1.3671	0.144	-	-	-	NA
Tumor size(cm)	≥5/<5	1.347	1.293	1.715	0.025	1.181	1.066	1.781	0.031
Differentiation grade	Poor/well+moderate	1.154	0.789	1.718	0.035	-	-	-	NS
Local invasion	pT3-4/pT1-2	1.981	1.3835	2.593	0.018	1.207	1.186	1.718	0.027
Lymph node metastasis	N2/N0+N1	2.463	1.892	2.796	0.002	1.434	1.389	1.759	0.014
TNM stage	Ⅲ/Ⅰ+Ⅱ	2.515	1.782	2.816	0.001	1.132	1.089	1.878	0.035
CA19-9 (KU/L)	≥37/<37	1.514	0.782	1.941	0.064	-	-	-	NA
CEA (ng/mL)	≥5/<5	1.178	1.082	1.519	0.043	-	-	-	NS
miR-365a-3p	low/high	1.473	1.334	1.683	0.024	1.277	1.128	1.661	0.039

Note. NA: not adopted; NS: not significant.