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. 2020 Mar 4;10(10):4334–4348. doi: 10.7150/thno.42982

Figure 1.

Figure 1

miR-128 levels positively correlate with increased bone resorption in mouse/human bone specimens and mouse primary BMMs. A BMD of the control group and the PMOP group. Mean ± SD, n = 10 biologically independent samples, **P < 0.01 by Student's t-test. B qRT-PCR analysis showed that miR-128 and Nfatc1 mRNA expression levels significantly increased in PMOP patients-derived bone tissues. Mean ± SD, n = 10 biologically independent samples, **P < 0.01 by Student's t-test. C Correlation analysis demonstrated that the expression levels of miR-128 and Nfatc1 mRNA increased along with the decrease in BMD levels in PMOP patients. n = 10 biologically independent samples. D Correlation analysis demonstrated that miR-128 expression levels are positively correlated with increased Nfatc1 mRNA levels in bone tissues from PMOP patients. n = 10 biologically independent samples. E, F qRT-PCR analysis showed that miR-128 and Nfatc1 mRNA expression levels significantly increased in OVX mice-derived bone tissues and BMMs. Mean ± SD, n = 8 biologically independent samples, **P < 0.01 by Student's t-test.