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. 2020 Mar 26;10(10):4705–4719. doi: 10.7150/thno.42417

Figure 3.

Figure 3

CircSAMD4A as an independent risk factor that can predict non-remission in the obese patients. (A) CircSAMD4A expression in adipose tissues from 40 obese patients and 20 lean patients. (B) Pearson correlation between circSAMD4A expression and BMI in adipose tissues of 60 obese patients. (C) ROC curve for circSAMD4A indicating its diagnostic value in obese patients. (D) Schematic representation the siRNA sites specific to the back-splice junction of circSAMD4A. (E) Expression of circSAMD4A following siRNA treatment using qRT-PCR. (F-G) C/EBP-α and PPAR-γ expression was quantified using qRT-PCR after circSAMD4A knockdown during preadipocytes differentiation. (H) C/EBP-α and PPAR-γ expression was quantified using Western blot assay after circSAMD4A knockdown during preadipocyte differentiation. Data are presented as means ± SD; significant difference was identified with Student's t test. *P < 0.05; **P < 0.01; ns (not significant).