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. 2020 Mar 15;10(10):4614–4626. doi: 10.7150/thno.37965

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A: The estimated median Young's modulus measured in vivo in normal murine pancreas (n = 18). YM = (4.2 ± 1.3) kPa, in non-neoplastic pancreas with less than 50 % fibrosis (n = 18). YM = (4.7 ± 1.1) kPa, in non-neoplastic pancreas with more than 50% fibrosis (n = 8). YM = (7.2 ± 2.3) kPa, and in pancreatic tumors (n = 5). YM = (11.3 ± 1.7) kPa. (One-Way ANOVA: **P < 0.0025, ***P < 0.0003, ****P < 0.0001). B: Estimated median Young's modulus values vs. PSR density percentage using Picrosirius red staining. This method was applied on 5 of the total normal pancreata, PSR= (2 ± 0.8) %, on 17 of the non-neoplastic fibrotic pancreatitis cases, PSR = (9.8 ± 3.4) %, and on 4 with PDAC, PSR = (13.2 ± 1.2) %.