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. 2020 Mar 15;10(10):4614–4626. doi: 10.7150/thno.37965

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A: Surgical pancreatic human specimens. a: Gross photograph of PDAC tumor and its surrounding tissue in cross section. b: B-mode image of PDAC tumor and its surrounding tissue. c: 2D Young's modulus map overlaid on B-mode image. The estimated median Young's modulus for tumor part, red/orange/yellow part is (YM = 44.9 kPa). The estimated median Young's modulus for perilesional part, light blue part, is (YM = 19.2 kPa). The estimated median Young's modulus for non-neoplastic part, dark blue part is (YM = 3.8 kPa). d: Picrosirius red stain of a PDAC tumor, 20x magnification (PSR, density = 53.2 %). e: Picrosirius red stain of the perilesional region surrounding the PDAC tumor, 20x magnification (PSR, density = 35 %). f: Picrosirius red stain of the non-neoplastic pancreas adjacent to PDAC tumor, 20x magnification (PSR, density = 4.6 %). g: Mason's trichrome stain of PDAC tumor, 20x magnification. h: Mason's trichrome stain of the perilesional region of PDAC tumor, 20x magnification. i: Mason's trichrome stain of non-neoplastic pancreas adjacent to PDAC tumor, 20x magnification. B: Human surgical pancreatic specimens with history of neoadjuvant treatment. (Gemcitabin / Abraxane, 6 months). a: Gross photograph of PDAC tumor, status post neoadjuvant treatment, and its surrounding tissue in cross section. b: B-mode image of PDAC status post neoadjuvant treatment and its surrounding tissue. c: 2D Young's modulus map overlaid on B-mode image. The estimated median Young's modulus for tumor part, red/orange/yellow area, is (YM = 35.3 kPa). The estimated median Young's modulus for the perilesional region, light blue part, is (YM = 18 kPa). The estimated median Young's modulus for non-neoplastic part, dark blue part is (YM = 3.1 kPa). d: Picrosirius red stain of PDAC tumor status post neoadjuvant treatment, 20x magnification (PSR, density = 47.1 %). e: Picrosirius red stain of the perilesional region of PDAC tumor, 20x magnification (PSR, density = 35.4 %). f: Picrosirius red stain of non-neoplastic pancreas adjacent to PDAC tumor, 20x magnification (PSR, density = 6.6 %). g: Mason's trichrome stain of PDAC tumor status post neoadjuvant treatment, 20x magnification. h: Mason's trichrome stain of the perilesional region of PDAC tumor status post neoadjuvant treatment, 20x magnification. i: Mason's trichrome stains of the non-neoplastic pancreas adjacent to PDAC tumor, 20x magnification. C: Human surgical pancreatic specimens with history of neoadjuvant treatment. Chemo/radiation (Gemcitabin /Abraxane, 3 months, accompanied by IMRT intensity-modulated radiation therapy of 50.4 Gy)) a: Gross photograph of PDAC tumor and its surrounding tissue in cross section. b: B-mode image of PDAC and its surrounding tissue. c: 2D Young's modulus map overlaid on B-mode image. The estimated median Young's modulus for tumor part, red/orange/yellow part, is (YM = 40 kPa). The estimated median Young's modulus for perilesional region of PDAC tumor, light blue area, is (YM =17.2 kPa). The estimated median Young's modulus for the non-neoplastic pancreas adjacent to PDAC tumor, dark blue, is (YM =2.9 kPa). d: Picrosirius red stain of PDAC tumor status post neoadjuvant treatment, 20x magnification (PSR, density = 57 %). e: Picrosirius red stain of the perilesional region of a PDAC tumor status post neoadjuvant treatment, 20x magnification (PSR, density = 23.6 %). f: Picrosirius red stain of non-neoplastic pancreas adjacent to a PDAC tumor status post neoadjuvant treatment, 20x magnification (PSR, density = 5 %). g: Mason's trichrome stain of PDAC tumor status post neoadjuvant treatment, 10x magnification. h: Mason's trichrome stain of the perilesional region of a PDAC tumor status post neoadjuvant treatment, 10x magnification. i: Mason's trichrome stain of non-neoplastic pancreas adjacent to a PDAC tumor status post neoadjuvant treatment, 10x magnification. Scale bars for Masson's trichrome and Picrosirius stain images displayed as are equal to 200µm.

Inline graphic — A: Surgical pancreatic human specimens. a: Gross photograph of PDAC tumor and its surrounding tissue in cross section. b: B-mode image of PDAC tumor and its surrounding tissue. c: 2D Young's modulus map overlaid on B-mode image. The estimated median Young's modulus for tumor part, red/orange/yellow part is (YM = 44.9 kPa). The estimated median Young's modulus for perilesional part, light blue part, is (YM = 19.2 kPa). The estimated median Young's modulus for non-neoplastic part, dark blue part is (YM = 3.8 kPa). d: Picrosirius red stain of a PDAC tumor, 20x magnification (PSR, density = 53.2 %). e: Picrosirius red stain of the perilesional region surrounding the PDAC tumor, 20x magnification (PSR, density = 35 %). f: Picrosirius red stain of the non-neoplastic pancreas adjacent to PDAC tumor, 20x magnification (PSR, density = 4.6 %). g: Mason's trichrome stain of PDAC tumor, 20x magnification. h: Mason's trichrome stain of the perilesional region of PDAC tumor, 20x magnification. i: Mason's trichrome stain of non-neoplastic pancreas adjacent to PDAC tumor, 20x magnification. B: Human surgical pancreatic specimens with history of neoadjuvant treatment. (Gemcitabin / Abraxane, 6 months). a: Gross photograph of PDAC tumor, status post neoadjuvant treatment, and its surrounding tissue in cross section. b: B-mode image of PDAC status post neoadjuvant treatment and its surrounding tissue. c: 2D Young's modulus map overlaid on B-mode image. The estimated median Young's modulus for tumor part, red/orange/yellow area, is (YM = 35.3 kPa). The estimated median Young's modulus for the perilesional region, light blue part, is (YM = 18 kPa). The estimated median Young's modulus for non-neoplastic part, dark blue part is (YM = 3.1 kPa). d: Picrosirius red stain of PDAC tumor status post neoadjuvant treatment, 20x magnification (PSR, density = 47.1 %). e: Picrosirius red stain of the perilesional region of PDAC tumor, 20x magnification (PSR, density = 35.4 %). f: Picrosirius red stain of non-neoplastic pancreas adjacent to PDAC tumor, 20x magnification (PSR, density = 6.6 %). g: Mason's trichrome stain of PDAC tumor status post neoadjuvant treatment, 20x magnification. h: Mason's trichrome stain of the perilesional region of PDAC tumor status post neoadjuvant treatment, 20x magnification. i: Mason's trichrome stains of the non-neoplastic pancreas adjacent to PDAC tumor, 20x magnification. C: Human surgical pancreatic specimens with history of neoadjuvant treatment. Chemo/radiation (Gemcitabin /Abraxane, 3 months, accompanied by IMRT intensity-modulated radiation therapy of 50.4 Gy)) a: Gross photograph of PDAC tumor and its surrounding tissue in cross section. b: B-mode image of PDAC and its surrounding tissue. c: 2D Young's modulus map overlaid on B-mode image. The estimated median Young's modulus for tumor part, red/orange/yellow part, is (YM = 40 kPa). The estimated median Young's modulus for perilesional region of PDAC tumor, light blue area, is (YM =17.2 kPa). The estimated median Young's modulus for the non-neoplastic pancreas adjacent to PDAC tumor, dark blue, is (YM =2.9 kPa). d: Picrosirius red stain of PDAC tumor status post neoadjuvant treatment, 20x magnification (PSR, density = 57 %). e: Picrosirius red stain of the perilesional region of a PDAC tumor status post neoadjuvant treatment, 20x magnification (PSR, density = 23.6 %). f: Picrosirius red stain of non-neoplastic pancreas adjacent to a PDAC tumor status post neoadjuvant treatment, 20x magnification (PSR, density = 5 %). g: Mason's trichrome stain of PDAC tumor status post neoadjuvant treatment, 10x magnification. h: Mason's trichrome stain of the perilesional region of a PDAC tumor status post neoadjuvant treatment, 10x magnification. i: Mason's trichrome stain of non-neoplastic pancreas adjacent to a PDAC tumor status post neoadjuvant treatment, 10x magnification. Scale bars for Masson's trichrome and Picrosirius stain images displayed as are equal to 200µm.