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. 2020 Mar 15;10(10):4466–4480. doi: 10.7150/thno.42478

Figure 1.

Figure 1

REV-ERBs agonists SR9009 is lethal in both Chemosensitive cells and their corresponding chemotherapy-resistant cells. (A and B) Chemosensitive cells (H69 and H446) were incubated for 72 h in the presence or absence of different concentrations of SR9009. (C and D) chemotherapy-resistant cells (H69AR and H446DDP) were treated with different concentrations of SR9009 for 72 h. (A-D) The data are presented as means ± S.D. of three independent experiments. (E and F) Cell migration ability was studied by scratch-wound assay. After being washed by PBS, the wound areas were photographed at 0 h, 12 h, 24 h, 48 h and 72 h. The percent wound closure = (the width of the wound at 72 h - the width of the wound at 0 h)/the width of the wound at 0 h. The data are presented as means ± S.D. of three independent experiments. *P < 0.05; **P < 0.01. (G and H) Transwell assays were performed to investigate changes in cell migration and invasiveness. Error bars, mean ± SD from three independent experiments. *P < 0.05; **P < 0.01.