Figure 5.
Reward-evoked corticostriatal theta synchrony predicts motivational state in WT but not HD rats. Among all WT animals, higher peak reward-evoked PFC–NAc coherence in the theta frequency range (3.1–7 Hz) was correlated with a greater number of reinforcers earned on the PR task (n = 17; R2 = 0.4188, P < 0.01). Consistent with abnormally elevated reward-evoked theta coherence in the Tg5 animals across all ages, no strong relationship among theta coherence and PR task performance was measured in the Tg5 rats (n = 18; R2 = 0.01913, ns).