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. 2020 Feb 5;253(2):87–99. doi: 10.1007/s00232-020-00108-3

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© The Author(s) 2020

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Fig. 4 — Illustration of electrostatic interactions between E146–R92 (a), R218–E220 (b), and R333–E329 (c), as summarized in Table 1. The right hand panels depict non-local interactions stabilizing distinct conformation. d Modeling of K256 in the central pore (upper panel). The K256V mutation is predicted to cause hydrophobic interaction (lower panel)