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. 2020 Apr 7;13:1061–1075. doi: 10.2147/DMSO.S243560

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© 2020 Wang et al.

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RSV prevents T2DM-induced hippocampal oxidative stress. (A) Detection of 3-NT expression, an indicator of protein nitrification, in the hippocampus by Western blotting to assess oxidative damage. (B) Micrographs of coimmunolabelling with the DNA oxidation markers 8-OHdG (green), GFAP (red) and DAPI (blue) in the hippocampus. The mice hippocampus showed 8-OHdG (green) immunolabeling in neurons (DAPI, blue) and some glial (GFAP, red) cells (Scale bar=10 μm). (C) The determination of malondialdehyde (MDA) content reflected the degree of lipid peroxidation in the hippocampus, and indirectly reflected the degree of neuron damage. The data are expressed as the mean ± SD (n = 3). **P < 0.01 vs Ctrl; ^##P < 0.01vs. DM.

Abbreviations: 3-NT, 3-nitrotyrosine; 8-OHdG, 8-hydroxyguanosine; GFAP, glial fibrillary acidic protein; DAPI, 4.6-diamidino-2-phenylindole; MDA, malondialdehyde.