Table 1.
Univariate and multivariate Cox regression analyses of overall survival in patients with colon cancer in GSE41258.
| Variables | Total n = 167n (%) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | ||
| Age | |||||
| <60 | 54 (32.3%) | 1 (reference) | |||
| ≥60 | 113 (67.7%) | 1.239 (0.782–1.963) | 0.361 | ||
| Sex | |||||
| Male | 88 (52.7%) | 1 (reference) | |||
| Female | 79 (47.3%) | 0.661 (0.433–1.008) | 0.054 | ||
| Group stage | |||||
| I+II | 69 (41.3%) | 1 (reference) | 1 (reference) | ||
| III+IV | 98 (58.7%) | 4.006 (2.461–6.523) | 0.000 | 0.679 (0.275–1.679) | 0.402 |
| T stage | |||||
| T1+T2 | 33 (19.8%) | 1 (reference) | 1 (reference) | ||
| T3+T4 | 134 (80.2%) | 2.531 (1.312–4.884) | 0.006 | 1.219 (0.607–2.446) | 0.578 |
| N stage | |||||
| N0 | 84 (50.3%) | 1 (reference) | 1 (reference) | ||
| N1+N2 | 83 (49.7%) | 2.361 (1.550–3.597) | 0.000 | 2.572 (1.292–5.119) | 0.007 |
| M stage | |||||
| No | 114 (68.3%) | 1 (reference) | 1 (reference) | ||
| Yes | 53 (31.7%) | 9.878 (6.295–15.500) | 0.000 | 11.195 (5.949–21.070) | 0.000 |
| P53 mutant | |||||
| Wild type | 46 (27.5%) | 1 (reference) | |||
| Mutant | 83 (49.7%) | 1.118 (0.696–1.795) | 0.646 | ||
| Missing | 39 (23.4%) | ||||
Characteristics with significant P values after univariate analysis were screened by multivariate analysis. HR: hazard ratio; CI: confidence interval; TNM: tumor-node-metastasis.