Table 1.
Proliferation of mononuclear cells after 100 ng/mL, 10 ng/mL and 1 ng/mL DON exposure. Values are expressed as stimulation indices (ratios between counts per minute (CPM) of mitogen stimulated cells and CPM of non-stimulated cells) mean ± standard deviation. Data of PBMC samples are from nine pigs in triplicate. Statistically significant differences between DON exposed samples and control samples are marked with asterisks (* p ≤ 0.05; ** p ≤ 0.01).
| Time of Stimulation | Mitogen | Control | DON 100 ng/mL | DON 10 ng/mL | DON 1 ng/mL |
|---|---|---|---|---|---|
| 18 h | ConA | 65.55 ± 23.47 | 39.31 ± 21.19 * | 54.05 ± 37.55 | 50.63 ± 28.83 |
| PHA | 9.77 ± 5.61 | 10.71 ± 5.78 | 5.69 ± 3.21 | 9.75 ± 8.32 | |
| PWM | 86.63 ± 39.08 | 47.47 ± 23.37 ** | 69.04 ± 42.59 | 69.67 ± 37.81 | |
| 5 days | ConA | 12.62 ± 11.31 | 8.74 ± 7.26 | 8.66 ± 10.51 | 8.93 ± 6.90 |
| PHA | 7.60 ± 6.06 | 6.74 ± 6.30 | 6.34 ± 3.97 | 10.08 ± 5.85 | |
| PWM | 13.37 ± 8.83 | 8.27 ± 6.54 * | 16.73 ± 15.84 | 18.19 ± 15.51 |