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Dissolution procedure: (stomach) Formulation disperses for 30 min in 0.1 M hydrochloric acid; (early small intestine) addition of surfactant concentrate after 30 min, buffer concentrate to reach pH 5.5, and overlaying of the aqueous phase with 50 mL of 1-decanol; (late small intestine) stepwise pH-adjustment at 90 min to reach pH 6.8. The grey line in the background represented measured human gastrointestinal pH-profile [22].
