Figure 1.

Proliferative responses to the overlapping peptides of VP1 in CVB3-infected animals. A/J mice were infected with CVB3, and at termination on day 21 post-infection, splenocytes were prepared. Cells were stimulated with or without the overlapping peptides of VP1 or control (RNase 43–56) for 2 days, and after pulsing with ³[H] thymidine for 16 h, proliferative responses were measured as cpm. Stimulation indices were derived by dividing the cpm values of peptide-stimulated cells (100 µg/mL) by those of medium control. Representative data set obtained from three individual experiments, each involving 10 to 12 mice are shown. * p ≤ 0.05, and ** p ≤ 0.01.