Figure 5.

Evaluation of disease severity induced with CVB4 in A/J mice. (a) Body weight. A/J mice were infected with or without CVB4 and their body weights were noted up to 16 days post-infection. (b) Survival rates. The above mice were monitored for mortality post-infection and their survival rates were calculated. Data from two individual experiments, each involving four to eight mice are shown. (c) Histopathology. Hearts and pancreata collected at termination on day 16 post-infection with CVB4 were evaluated for inflammatory changes. While, heart (i) and pancreatic (ii) sections from control group were normal, sections from CVB4-infected mice had hemorrhagic necrosis, fibrosis, mineralization and inflammation in heart (iii), and atrophy (iv) and inflammation (v) in the pancreas. Original magnification, ×40. Representative data from the above experiments are shown. * p ≤ 0.05.