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. 2020 Mar 5;12(3):233. doi: 10.3390/pharmaceutics12030233

Table 4.

Polymeric nanoparticles used in cancer therapy.

Gene Delivery Description Implication in Tumor Eradication Reference
In Vitro In Vivo
siRNA 1 Hyaluronic-acid-modified chitosan nanoparticles labeled with Cyanine 3 (Cy3) to deliver BCL2 siRNA to A549 cell line Nanoformulations induced inhibition of cell proliferation via BCL2 downregulation [234]
siRNA Analysis of alkylation effect in alkylated cationic curdlan nanoparticles as STAT3 siRNA carriers Alkylation significantly reduces the cytotoxicity of aminated curdlan in human HepG2 and murine B16 cell lines [235]
siRNA Polymeric nanoparticle based on curdlan loaded with FITC or Plk1 2 siRNA in a pH dependent manner Curimi polymers enhanced endosomal escape and efficiently delivered siRNAs to Hela and HepG2 cells resulting in cell growth inhibition and DNA damage [236]
pDNA 3 Analysis of effect of polymeric particles with pH dependent switching surface charge, carrying FITC-pDNA 3 Nanoformulations efficiently transfected Hela cells in a pH dependent manner [237]
siRNA Polyethylenimine polymeric particles complexed with extracellular vesicles (EVs) combined for siRNA and anti-miRNA 4 delivery Ddose-dependent inhibition of miRNAs. Differences in the polymer/siRNA efficacies between ECVs from different cell lines, regardless of the target cell line Xenographts size decreased after 12 days of treatment in mice model after intravenous injection [233]

1 siRNA: small interfering RNA; 2 Plk1: Plo-like kinase-1; 3 FITC-pDNA: plasmid DNA containing fluorescein-5-isothiocyanate gene. 4 miRNA: microRNA.