Table 4.

Polymeric nanoparticles used in cancer therapy.

Gene Delivery	Description	Implication in Tumor Eradication		Reference
		In Vitro	In Vivo
siRNA 1	Hyaluronic-acid-modified chitosan nanoparticles labeled with Cyanine 3 (Cy3) to deliver BCL2 siRNA to A549 cell line	Nanoformulations induced inhibition of cell proliferation via BCL2 downregulation		[234]
siRNA	Analysis of alkylation effect in alkylated cationic curdlan nanoparticles as STAT3 siRNA carriers	Alkylation significantly reduces the cytotoxicity of aminated curdlan in human HepG2 and murine B16 cell lines		[235]
siRNA	Polymeric nanoparticle based on curdlan loaded with FITC or Plk1 2 siRNA in a pH dependent manner	Curimi polymers enhanced endosomal escape and efficiently delivered siRNAs to Hela and HepG2 cells resulting in cell growth inhibition and DNA damage		[236]
pDNA 3	Analysis of effect of polymeric particles with pH dependent switching surface charge, carrying FITC-pDNA 3	Nanoformulations efficiently transfected Hela cells in a pH dependent manner		[237]
siRNA	Polyethylenimine polymeric particles complexed with extracellular vesicles (EVs) combined for siRNA and anti-miRNA 4 delivery	Ddose-dependent inhibition of miRNAs. Differences in the polymer/siRNA efficacies between ECVs from different cell lines, regardless of the target cell line	Xenographts size decreased after 12 days of treatment in mice model after intravenous injection	[233]

¹ siRNA: small interfering RNA; ² Plk1: Plo-like kinase-1; ³ FITC-pDNA: plasmid DNA containing fluorescein-5-isothiocyanate gene. ⁴ miRNA: microRNA.