Table 5.

Actual experiments conducted and responses observed using the hybrid Design of Experiments (DOE).

Run	HPMC-AS (g)	Eudragit®L100 (g)	Homogenisation Speed (rpm)	Yield (%)	INH Released at 4 h (%)	INH Released at 12 h (%)	Encapsulation Efficiency (%)	INH Released at 24 h (%)
1	3.41	2.00	1500	51.32	17.45	45.35	89.67	80.26
2	2.00	2.00	2000	43.30	29.74	64.44	72.57	89.56
3	2.00	2.00	500	56.52	23.30	55.35	77.42	87.45
4	3.00	3.00	2500	48.32	19.05	36.25	65.16	71.28
5	0.485	2.00	1500	21.91	38.42	65.41	50.51	93.16
6	3.00	1.00	2500	45.83	39.33	53.99	70.99	88.67
7	1.00	3.00	2500	40.00	13.02	59.45	68.65	95.20
8	2.00	0.485	1500	21.14	71.04	55.78	55.48	89.81
9	2.00	2.00	3500	31.83	36.66	68.89	60.84	93.58
10	1.00	1.00	2500	22.27	45.86	67.51	66.72	90.96
11	2.00	3.41	1500	47.17	8.82	47.75	89.41	87.87