Table 10.

Summary of best fit models, significant factors, and equations describing the relationship between input variables and response for RIF microspheres.

Response	Fitting Model	Significant Factors	Equation
% RIF released at 0.5 h = R1	Quadratic	A-Eudragit® RLPO B-Ethylcellulose C-d-glucose	R1 = 7.46 − 2.19 − 6.47B + 1.05C + 0.76AB − 0.14AC + 0.45BC − 1.12A2 + 3.57B2 − 0.78C2
% RIF released at 2 h = R2	Quadratic	A-Eudragit® RLPO B-Ethylcellulose	R2 =34.44 − 6.59A − 6.42B + 2.42 C + 4.93AB − 1.14 AC + 1.55BC − 6.00A2 − 7.86B2 − 4.37C2
% RIF released at 4 h = R3	Quadratic	B-Ethylcellulose C-d-glucose	R3 = 47.3 − 0.54A − 8.47B + 2.03 C + 0.41AB − 0.53AC + 2.06BC − 3.94A2 − 2.29B2 − 4.65C2
% RIF released at 6 h = R4	Linear	B-Ethylcellulose C-d-glucose	R4 = 67.00 − 2.15A − 7.44B + 3.32C
% RIF released at 8 h = R5	Quadratic	A-Eudragit® RLPO B-Ethylcellulose C-d-glucose	R5 = 83.95 − 3.85A - 8.78B + 2.28C − 0.76AB + 1.12AC + 0.038BC − 3.01A2 − 4.23B2 − 1.92C2
Encapsulation efficiency (%) = R6	Quadratic	A-Eudragit® RLPO B-Ethylcellulose C-d-glucose	R6 = 77.46 + 9.44A + 4.29B − 1.26C − 2.51AB + 1.37AC + 0.32BC − 0.59A2 + 2.14B2 + 4.77C2
Buoyancy = R7	Quadratic	A-Eudragit® RLPO B-Ethylcellulose	R7 = 60.17 − 2.60A + 5.10B + 2.07C
Lag time (s) = R8	Quadratic	A-Eudragit® RLPO B-Ethylcellulose C-d-glucose	R8 =151.00 + 52.88A − 19.75B + 13.13C − 39.25AB − 2.50AC + 13.75BC − 19.00A2 − 30.25B2 − 14.50C2
% RIF released at 12 h = R9	Quadratic	A-Eudragit® RLPO B-Ethylcellulose C-d-glucose	R9 = 90.37 − 2.12A − 7.80B + 3.04 C + 0.17AB + 1.54 AC + 1.61BC − 4.14A2 + 0.74B2 − 1.29C2
% Yield = R10	Quadratic	A-Eudragit® RLPO B-Ethylcellulose	R10 = 71.16 + 8.60A + 5.34B − 0.90C − 0.80AB − 0.65AC + 1.04BC + 2.23A2 − 2.07B2 + 1.93C2