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. 2020 Mar 5;12(3):234. doi: 10.3390/pharmaceutics12030234

Table 11.

Prediction accuracy for the Box Behnken design optimization process.

Batch	Response	Prediction Accuracy
Batch	Response	Predicted	Actual	Residual	% P.E.
A	% RIF released at 0.5 h (R₁)	15.39	15.65	0.26	1.66
	% RIF released at 2 h (R₂)	36.99	38.04	1.05	2.76
	% RIF released at 4 h (R₃)	48.58	49.18	0.6	1.22
	% RIF released at 6 h (R₄)	68.71	65.70	3.01	4.58
	% RIF released at 8 h (R₅)	76.55	78.55	2	2.55
	Encapsulation efficiency (%) (R₆)	94.71	94.80	0.09	0.095
	% Buoyancy (R₇)	62.23	58.62	3.61	6.16
	Floating lag time (seconds) (R₈)	149.63	144	5.63	3.91
	% RIF released at 12 h (R₉)	92.12	87.89	4.23	4.81
	% Yield (R₁₀)	82.19	81.95	0.24	0.29
B	% RIF released at 0.5 h (R₁)	15.39	15.81	0.42	2.66
	% RIF released at 2 h (R₂)	36.99	38.58	1.59	4.12
	% RIF released at 4 h (R₃)	48.58	49.11	0.53	1.08
	% RIF released at 6 h (R₄)	68.71	64.57	4.14	6.41
	% RIF released at 8 h (R₅)	76.55	77.08	0.53	0.688
	Encapsulation efficiency (%) (R₆)	94.71	99.19	4.48	4.52
	% Buoyancy (R₇)	62.23	56.22	6.01	10.69
	Floating lag time (seconds) (R₈)	149.63	140	9.63	6.88
	% RIF released at 12 h (R₉)	92.12	86.44	5.68	6.57
	% Yield (R₁₀)	82.19	87.97	5.78	6.57
C	% RIF released at 0.5 h (R₁)	15.39	16.03	0.64	3.99
	% RIF released at 2 h (R₂)	36.99	39.32	2.33	5.93
	% RIF released at 4 h (R₃)	48.58	47.22	1.36	2.88
	% RIF released at 6 h (R₄)	68.71	66.73	1.98	2.97
	% RIF released at 8 h (R₅)	76.55	78.44	1.89	2.41
	Encapsulation efficiency (%) (R₆)	94.71	96.99	2.28	2.35
	% Buoyancy (R₇)	62.23	55.81	6.42	11.50
	Floating lag time (seconds) (R₈)	149.63	142	7.63	5.37
	% RIF released at 12 h (R₉)	92.12	94.71	2.59	2.74
	% Yield (R₁₀)	82.19	85.88	3.69	4.20