Table 1.
Recombinant Loxosceles phospholipases-D (PLDs) and their main activities.
| Recombinant Loxosceles PLDs | Known Activity | References | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Species | Name | GenBank Acession Number | Dermonecrosis | Hemolysis | Sphingo-myelinase | In vitro Platelet Aggregation | Vasc. Perm. Increase | Inflammat. | Lethality | Nephrotox | Edema | Cardiotox | Insecticidal | |
| L. intermedia | LiRecDT1; LiSicTox-alphaIA1a |
ABA62021, P0CE80 |
Yes | Yes (Direct/C-dep) |
Yes | Yes | Yes | Yes | Yes | Yes | Yes | − | Yes | [9,47,53,54], This work |
| LiD1 | AAQ16123 | Yes | Yes (C-dep) | Yes | Yes | − | − | − | − | Yes | Yes | − | [45,55,56,57] | |
| LiRecDT2; LiSicTox-alphaIA2aii |
ABB69098, P0CE83 |
Yes | Yes (Direct) | Yes | Yes | Yes | Yes | Yes | − | Yes | − | − | [13,15,54] | |
| LiRecDT3 | ABB71184 | No | No | No | No | No | ± | No | − | No | − | − | [13,15] | |
| LiRecDT4 | ABD91846 | Yes | − | Yes | ± | Yes | Yes | − | − | Yes | − | − | [14] | |
| LiRecDT5 | ABD91847 | No | − | No | No | No | ± | − | − | Yes | − | − | [14] | |
| LiRecDT6 | ABO87656 | Yes | − | Yes | Yes | Yes | Yes | Yes | − | Yes | − | − | [48] | |
| LiRecDT7 | AGN52903 | Yes | Yes (Direct) | Yes | − | Yes | Yes | − | − | − | − | [16] | ||
| L. laeta | Smase I/ LlSicTox-alphaIII1i |
AAM21154 | Yes | Yes (C-dep) | Yes | − | − | Yes | − | − | Yes | − | − | [18,46] |
| Ll1/LlSicTox-alphaIII1ii | ABD15447 | − | − | Yes | − | − | − | Yes | − | − | − | − | [51] | |
| LlPLD1 | ADP00408 | − | Yes (C-dep) | Yes | − | − | Yes | − | − | − | − | − | [52,58] | |
| LlPLD2 | ADP00409 | − | No | No | − | − | Yes | − | − | − | − | − | [52,58] | |
| Ll2/LlSicTox-alphaIII2 | ABD15448 | − | − | Yes | − | − | − | Yes | − | − | − | − | [51] | |
| Smase II/ LlSicTox-betaIA1 |
AAM21156 | ± | Yes (C-dep) | Yes | − | − | Yes | − | − | Yes | − | − | [18,46] | |
| L. reclusa | Smase D | AAW56831 | − | Yes (C-dep) | Yes | − | − | − | − | − | − | − | − | [27] |
| Lr1 | AAT66075 | − | − | Yes | − | − | − | Yes | − | − | − | − | [51] | |
| L. boneti | Lb1 | AAT66073 | − | − | Yes | − | − | − | Yes | − | − | − | − | [51] |
| Lb3 | AAT66074 | − | − | No | − | − | − | − | − | − | − | − | [51] | |
| L. arizonica | LarSicTox-alphaIB2bi | Q4ZFU2 | − | − | Yes | − | − | − | − | − | − | − | Yes | [12] |
| LarSicTox-betaID1 | AJV88487 | − | − | Yes | − | − | − | − | − | − | − | − | [30] | |
| L. gaucho | LgRec1 | AFY98967 | Yes | Yes (Direct) | Yes | Yes | − | − | − | − | Yes | − | − | [53] |