Table 5.

In vivo effects of zearalenone in different fish species. Effects were dose dependent.

Fish	Species	Dose (mg/kg)	Exposure Time	Effects	Ref.
Zebrafish	Danio rerio	0.001	140 days (life-cycle)	Increased weight gain and body length on female fish. Feminization—shift towards female sex. Induction of plasma vitellogenin in females. Increased condition factor of the next generation. Decreased reproductive performance of the next generation. Does not affect fertility, hatch, embryo survival and gonad morphology.	[136]
Zebrafish	Danio rerio	0.1–3.2	42 days	Reduced of the relative spawning frequency. Reduced relative fecundity. Induction of plasma vitellogenin in male fish.	[135]
Rainbow trout	Unspecified	2	96 weeks (life cycle)	Increased feeding efficiency and growth rate. Modulation of the adaptative and innate immune system. Inflammation likely caused by pathogen infection. Changes in kidney morphology leading to atypical kidney structure and fibrosis—reddish spots displaying disorganized kidney morphology with inflammatory areas and granulomatous structures, whiteish spots or translucent, whiteish nodules. Rupture blood cells. Kidney inflammation was suggested to be due to Tetracapsuloides bryosalmonae infection. Increased albumin to globulin ratio (although not statistically significant). Decreased in lymphocytes concentration.	[137]