Figure 1.

ZIKV infection activates IRE1α and induction of XBP1 targets. Cells were infected with ZIKV and RNA was harvested at the indicated number of days post infection (dpi). The relative mRNA abundance of ZIKV RNA (A) spliced XBP1 (B), ERDJ4 (C), and P58IPK (D) were determined by quantitative RT-PCR. Data are means ± SD of four replicates and are representative of at least two independent experiments. * p < 0.05, ** p < 0.001, by unpaired t test.