Table 2.
Estimation of true positive (TP), false positive (FP), true negative (TN), and false negative (FN) cases within the experimental groups of mice injected with P1-CF770, P7-CF770 or CF770 alone. The results obtained at 2 h after the injection of imaging probes were normalized to the signal measured on non-injected mice and exploited to finally estimate the sensitivity and specificity of the three near-infrared (NIR) imaging probes.
| Parameter | P1-CF770 | P7-CF770 | CF770 |
|---|---|---|---|
| TP T/MeanCLM + SD ≥ 2 |
1.4 | 2 | 2.5 |
| 1.3 | 2 | 1.6 | |
| 2 | 2.2 | 1.1 | |
| 0.7 | |||
| Number of cases | 1 | 3 | 1 |
| FP CLM/MeanT − SD > 0.5 |
0.7 | 0.4 | 0.9 |
| 0.5 | 0.5 | 0.6 | |
| 0.8 | 0.5 | 0.6 | |
| 0.5 | |||
| Number of cases | 2 | 0 | 3 |
| TN CLM/MeanCLM ≤ 1 |
1 | 0.8 | 1.4 |
| 0.7 | 1 | 0.9 | |
| 1.2 | 1.2 | 0.9 | |
| 0.9 | |||
| Number of cases | 2 | 2 | 3 |
| FN T/MeanT < 1 |
1 | 0.9 | 1.5 |
| 0.8 | 1 | 1 | |
| 1.3 | 1.1 | 0.7 | |
| 0.9 | |||
| Number of cases | 1 | 1 | 2 |
| Sensitivity | 50% | 75% | 25% |
| Specificity | 50% | 100% | 40% |
Note: T = tumor; CLM = contralateral muscle; SD = standard deviation.