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. 2020 Mar 9;9(3):52. doi: 10.3390/biology9030052

Figure 1.

Figure 1

Wnt-11 protein expression in prostate cancer (PCa). (A) Gleason score distribution of Wnt-11 expression shows Wnt-11 expression significantly correlates with Gleason grade (p < 0.05 between three groups) (B) Immunohistochemical analysis of Wnt-11: (i) low Gleason score, faint cytoplasmic expression (black arrow) and stromal smooth muscle (red arrow) are indicated; (ii) an example of Gleason grade 4 tumor; and (iii) a strongly positive Gleason 5 tumor showed upregulated cytoplasmic expression (scale bar 100 μm). (C) miR-21 expression distribution increases with the Gleason score (p < 0.05 between three groups) (D) In-situ hybridization of miR-21-staining in a low Gleason score: (i) no miR-21-staining in tumor cells (black arrow), (ii) upregulated miR-21 expression on an example of a Gleason grade 4 tumor, and (iii) a strong expression of an miR-21 Gleason 5 tumor (scale bar 75 μm). IHC: immunohistochemistry and ISH: in-situ hybridization.