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(A) In vitro release profile of CS–S, CH-loaded–PLGA–NPs, and chitosan-coated–CH-loaded–PLGA–NPs performed using the dialysis bag method, revealing the sustained release pattern of CH-loaded–PLGA–NPs and Chitosan-coated–CH-loaded–PLGA–NPs (mean ± SD, n = 3). (B) Ex vivo permeation profiles of developed chitosan-coated–CH-loaded–PLGA–NPs as compared with CH-loaded–PLGA–NPs and pure CH–S through goat nasal mucosa.
